H PRLA000102 D Homologous structure dereived matrix (HSDM) for alignment of distantly related sequences (Prlic et al., 2000) R PMID:10964983 A Prlic, A., Domingues, F.S. and Sippl, M.J. T Structure-derived substitution matrices for alignment of distantly related sequences J Protein Eng. 13, 545-550 (2000) M rows = ARNDCQEGHILKMFPSTWYV, cols = ARNDCQEGHILKMFPSTWYV 5.50 -2.24 8.59 -1.77 0.24 10.00 -2.38 -0.33 4.07 11.01 0.45 -6.29 -6.53 -6.98 19.05 -2.16 -0.74 1.42 1.10 -2.47 7.85 -0.47 2.83 -0.39 2.41 -4.70 3.16 8.43 0.63 -3.39 1.16 -3.91 -5.70 -0.24 -1.80 11.64 -3.01 0.70 1.77 0.32 -5.95 -2.24 -1.29 -1.24 15.72 -1.72 -3.93 -5.78 -6.18 -0.13 -3.26 -5.89 -8.58 -4.44 6.74 -1.09 -2.83 -5.64 -7.41 -0.82 -4.56 -5.62 -6.55 -2.49 3.86 6.38 -1.22 3.89 1.64 1.53 -6.65 3.24 3.08 -1.82 -0.17 -4.82 -5.91 8.23 0.16 -1.43 -4.67 -7.88 3.50 -1.76 -3.94 -5.29 -3.66 2.94 4.32 -5.47 10.21 -2.42 -4.36 -6.22 -5.06 1.72 -5.54 -4.44 -7.46 0.25 2.30 3.90 -6.19 2.66 9.14 -1.11 1.31 -3.23 0.81 -6.70 1.30 -0.43 -1.79 -3.55 -4.04 -2.88 -1.21 -2.02 -2.96 13.32 1.27 -0.50 1.54 2.34 1.08 2.59 0.42 0.63 -2.38 -4.67 -6.22 -0.27 -3.92 -5.03 -1.28 6.35 0.60 0.34 1.14 -1.36 -1.89 1.08 -0.61 -2.24 -1.14 -3.03 -2.40 -0.37 -5.18 -4.00 2.44 3.09 6.33 -2.61 1.02 -6.29 -5.63 -3.01 -4.30 -6.28 -4.77 -5.71 -0.26 -0.58 -5.45 4.28 6.49 -11.46 -4.44 -3.55 18.08 -4.22 -1.01 -0.93 -3.85 -0.44 -1.73 -4.50 -4.34 1.17 -0.08 1.81 -4.03 -4.95 5.38 -7.41 -4.17 -2.92 6.79 10.92 0.16 -3.80 -5.65 -6.10 1.32 -4.97 -4.23 -5.32 -1.63 5.23 2.28 -3.57 1.18 0.52 -2.31 -2.69 -0.23 -2.13 0.66 5.28 //